An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1
نویسندگان
چکیده
منابع مشابه
An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1
The Hedgehog signaling pathway is part of the ancient developmental-evolutionary animal toolkit. Frequently co-opted to pattern new structures, the pathway is conserved among eumetazoans yet flexible and pleiotropic in its effects. The Hedgehog receptor, Patched, is transcriptionally activated by Hedgehog, providing essential negative feedback in all tissues. Our locus-wide dissections of the c...
متن کاملEvolution of lineage-specific functions in ancient cis-regulatory modules
Morphological evolution is driven both by coding sequence variation and by changes in regulatory sequences. However, how cis-regulatory modules (CRMs) evolve to generate entirely novel expression domains is largely unknown. Here, we reconstruct the evolutionary history of a lens enhancer located within a CRM that not only predates the lens, a vertebrate innovation, but bilaterian animals in gen...
متن کاملFlexible collective communication tuning architecture applied to Open MPI
Collective communications are invaluable to modern high performance applications, although most users of these communication patterns do not always want to know their inner most working. The implementation of the collectives are often left to the middle-ware developer such as those providing an MPI library. As many of these libraries are designed to be both generic and portable the MPI develope...
متن کاملAn Integrated Predictor for Cis-Regulatory Modules
Various cis-regulatory module (CRM) predictors have been proposed in the last decade. Several well-established CRM predictors adopted different categories of prediction strategies, including window clustering, probabilistic modeling and phylogenetic footprinting. Appropriate integration of them has a potential to achieve high quality CRM prediction. This study analyzed four existing CRM predict...
متن کاملComparative genomics allows the discovery of cis-regulatory elements in mosquitoes.
The discovery and mapping of cis-regulatory elements is important for understanding regulation of gene transcription in mosquito vectors of human diseases. Genome sequence data are available for 3 species, Aedes aegypti, Anopheles gambiae, and Culex quinquefasciatus (Diptera: Culicidae), representing 2 subfamilies (Culicinae and Anophelinae) that are estimated to have diverged 145 to 200 millio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: eLife
سال: 2016
ISSN: 2050-084X
DOI: 10.7554/elife.13550